Intra-Arrest Cooling Improves Outcomes in a Murine Cardiac Arrest Model
نویسندگان
چکیده
منابع مشابه
Intra-arrest cooling improves outcomes in a murine cardiac arrest model.
BACKGROUND Recent clinical studies have demonstrated that hypothermia to 32 degrees to 34 degrees C provides significant clinical benefit when induced after resuscitation from cardiac arrest. However, cooling during the postresuscitation period was slow, requiring 4 to 8 hours to achieve target temperatures after return of spontaneous circulation (ROSC). Whether more rapid cooling would further...
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Over the past several years, the implementation of therapeutic hypothermia has provided an exciting opportunity toward improving survival from out-of-hospital cardiac arrest. There are compelling data to support the prompt use of therapeutic hypothermia for initial survivors from out-of-hospital cardiac arrest, but animal data have suggested that initiation of therapeutic hypothermia during the...
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AIMS OF STUDY We have previously demonstrated that early intra-nasal cooling improved post-resuscitation neurological outcomes. The present study utilizing a porcine model of prolonged cardiac arrest investigated the effects of intra-nasal cooling initiated at the start of cardiopulmonary resuscitation (CPR) on resuscitation success. Our hypothesis was that rapid nasal cooling initiated during ...
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RATIONALE Post-ischemic changes in cellular metabolism alter myocardial and neurological function. Pyruvate dehydrogenase (PDH), the limiting step in mitochondrial glucose oxidation, is inhibited by increased expression of PDH kinase (PDK) during ischemia/reperfusion injury. This results in decreased utilization of glucose to generate cellular ATP. Post-cardiac arrest (CA) hypothermia improves ...
متن کاملIntra-arrest-cooling PRO
Although targeted temperature management (TTM) has been widely implemented among comatose survivors after cardiac arrest (CA), there are still several unanswered issues, including the optimal time to initiate cooling. Experimental studies have showed that early cooling after return of spontaneous circulation (ROSC) provides better neurological protection than normothermia, while clinical studie...
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ژورنال
عنوان ژورنال: Circulation
سال: 2004
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000131940.19833.85